aCSF was removed by careful suctioning and replaced with aCSF containing vehicle (aCSF + aCSF), 100 ng/ml with carrier free adult recombinant Hepatocyte Growth Factor (HGF) (R and D Systems, MN, USA) in aCSF, 10 "10 M Hinge (Harding lab), 50 ng/ml in aCSF, 10 "10 M Dihexa (Harding lab) in aCSF, 10 "12 M Dihexa in aCSF or 50 ng/ml HGF + 10 " ' 2 M Dihexa in aCSF for 30 minutes at 37C with gentle rocking
Follow-up Repeat glucose and CMP-related markers after 4-12 weeks or sooner if vomiting, dehydration, or glucose symptoms occur
These pathways are posited to play a role in communicating stress signals and preparing the cell to counteract the incoming damage
This guide explains what CagriSema is, how it works, what the trials showed, and how it compares to Wegovy and Zepbound